研究内容

海馬と呼ばれる脳の部位が学習や記憶に重要であることが良く知られていますが、海馬は精神疾患の病因?病態にも関連があり、抗うつ薬などの治療薬の標的としても重要と考えられています。我々はこれまでの研究によって、海馬の神経細胞が抗うつ薬によって見かけ上若返る「脱成熟」現象など、抗うつ作用に関する多くの発見を報告してきました。現在は、うつ病予防の観点から、運動による海馬機能変化について研究を進めています。運動はうつ病の予防や治療に役立つことが知られていますが、最近の研究によってこの効果には海馬神経機能の調節が関与することが分かりました。さらに、ストレスを弾き返す働き（レジリエンス）を運動が増強することも分かってきました。これらの詳細を研究し、精神疾患の予防、つまり健康な心を作る方法を明らかにすることが今後の目標です。

Publications (Kobayashi, K.)

2024

Otsubo K, Sakashita N, Nishimoto Y, Sato Y, Tsutsui T, Kobayashi K, Suzuki K, Segi-Nishida E.
Role of desmoplakin in supporting neuronal activity, neurogenic processes, and emotional-related behaviors in the dentate gyrus. Frontiers in Neuroscience 18:1418058 (2024).

2022

Kobayashi K*, Shikano K, Kuroiwa M, Horikawa M, Ito W, Nishi A, Segi-Nishida E, Suzuki H.
Noradrenaline activation of hippocampal dopamine D1 receptors promotes antidepressant effects. Proceedings of the National Academy of Sciences of USA 119: e2117903119 (2022). *Corresponding author

Katayama K, Morimura N, Kobayashi K, Corbett D, Okamoto T, Ornthanalai VG, Matsunaga H, Fujita W, Matsumoto Y, Akagi T, Hashikawa T, Yamada K, Murphy NP, Nagao S, Aruga J.
Slitrk2 deficiency causes hyperactivity with altered vestibular function and serotonergic dysregulation. iScience 25: 104604 (2022).

2021

Asada-Utsugi M, Uemura K, Kubota M, Noda Y, Tashiro Y, Uemura TM, Yamakado H, Urushitani M, Takahashi R, Hattori S, Miyakawa T, Ageta-Ishihara N, Kobayashi K, Kinoshita M, Kinoshita A.
Mice with cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial learning tasks. Molecular Brain 14:23 (2021).

2020

Kobayashi K*, Mikahara Y, Murata Y, Morita D, Matsuura S, Segi-Nishida E, Suzuki, H.
Predominant role of serotonin at the hippocampal mossy fiber synapse with redundant monoaminergic modulation. iScience 23: 101025 (2020). *Corresponding author

2018

Kobayashi K*, Takagi T, Ishii S, Suzuki H, Miyakawa T.
Attenuated bidirectional short-term synaptic plasticity in the dentate gyrus of Schnurri-2 knockout mice, a model of schizophrenia. Molecular Brain 11: 56 (2018). *Corresponding author

Kobayashi K*, Suzuki H.
Synapse-selective rapid potentiation of hippocampal synaptic transmission by 7,8-dihydroxyflavone. Neuropsychopharmacology Reports 38:197-203 (2018). *Corresponding author

2017

Kobayashi K.
Activity modifies adult brain maturity Oncotarget 8: 46708-46709 (2017).

Imoto Y, Segi-Nishida E, Suzuki H, Kobayashi K*.
Rapid and stable changes in maturation-related phenotypes of the adult hippocampal neurons by electroconvulsive treatment Molecular Brain 10:8 (2017) *Corresponding author

Kobayashi K*, Imoto Y, Yamamoto F, Kawasaki M, Ueno M, Segi-Nishida E, Suzuki H.
Rapid and lasting enhancement of dopaminergic modulation at the hippocampal mossy fiber synapse by electroconvulsive treatment Journal of Neurophysiology 117: 284-289 (2017). *Corresponding author

2015

Imoto Y, Kira T, Sukeno M, Nishitani N, Nagayasu K, Nakagawa T, Kaneko S, Kobayashi K, Segi-Nishida E.
Role of the 5-HT4 receptor in chronic fluoxetine treatment-induced neurogenic activity and granule cell dematuration in the dentate gyrus. Molecular Brain 8:29 (2015).

2014

Hayashi Y, Nabeshima Y, Kobayashi K, Miyakawa T, Tanda K, Takao K, Suzuki H, Esumi E, Noguchi S, Matsuda Y, Sasaoka T, Noda T, Miyazaki J, Mishina M, Funabiki K, Nabeshima Y.
Enhanced stability of hippocampal place representation caused by reduced magnesium block of NMDA receptors in the dentate gyrus. Molecular Brain 7: 44 (2014).

Onouchi T, Kobayashi K*, Sakai K, Shimomura A, Smits R, Sumi-Ichinose C, Kurosumi M, Takao K, Nomura R, Iizuka-Kogo A, Suzuki H, Kondo K, Akiyama T, Miyakawa T, Fodde R, Senda T.
Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia. Molecular Brain 7: 21 (2014). *Corresponding author

2013

Kobayashi K*, Ikeda Y, Asada M, Inagaki H, Kawada T, Suzuki H.
Corticosterone facilitates fluoxetine-induced neuronal plasticity in the hippocampus. PLoS One 8(5): e63662 (2013). *Corresponding author

Shin R, Kobayashi K, Hagihara H, Kogan JH, Miyake S, Tajinda K, Walton NM, Gross AK, Heusner CL, Chen Q, Tamura K, Miyakawa T, Matsumoto M.
The immature dentate gyrus represents a shared phenotype of mouse models of epilepsy and psychiatric disease. Bipolar Disorders 15: 405-421 (2013).

Ohira K, Kobayashi K, Toyama K, Nakamura HK, Shoji H, Takao K, Takeuchi R, Yamaguchi S, Kataoka M, Otsuka S, Takahashi M, Miyakawa T.
Synaptosomal-associated protein 25 mutation induces immaturity of the dentate granule cells of adult mice. Molecular Brain 6: 12 (2013).

Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T.
Deficiency of schnurri-2, an MHC enhancer binding protein, induces Mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia. Neuropsychopharmacology 38: 1409-1425 (2013).

2012

Nagura H, Ishikawa Y, Kobayashi K, Takao K, Tanaka T, Nishikawa K, Tamura H, Shiosaka S, Suzuki H, Miyakawa T, Fujiyoshi Y, Doi T.
Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice. Molecular Brain 5: 43 (2012).

Kobayashi K*, Haneda E, Higuchi M, Suhara T, Suzuki H.
Chronic fluoxetine selectively upregulates dopamine D1-like receptors in the hippocampus. Neuropsychopharmacology 37: 1500-1508 (2012). * Corresponding author

2011

Kobayashi K*, Umeda-Yano S, Yamamori H, Takeda M, Suzuki H, Hashimoto R.
Correlated alterations in serotonergic and dopaminergic modulations at the hippocampal mossy fiber synapse in mice lacking dysbindin. PLoS One 6: e18113 (2011). * Corresponding author

Kobayashi K*, Ikeda Y, Suzuki H.
Behavioral destabilization induced by the selective serotonin reuptake inhibitor fluoxetine. Molecular Brain 4:12 (2011). * Corresponding author

2010

Kobayashi K.
Hippocampal mossy fiber synaptic transmission and its modulation. Vitamins and Hormones 82: 65-85 (2010).

Kobayashi K*, Ikeda Y, Sakai A, Yamasaki N, Haneda E, Miyakawa T, Suzuki H.
Reversal of hippocampal neuronal maturation by serotonergic antidepressants. Proceedings of the National Academy of Sciences USA 107: 8434-8439 (2010). * Corresponding author

2009

Kobayashi K.
Targeting the hippocampal mossy fiber synapse for the treatment of psychiatric disorders. Molecular Neurobiology 39: 24-36 (2009).

2008

Yamasaki N, Maekawa M, Kobayashi K, Kajii Y, Maeda J, Soma M, Takao K, Tanda K, Ohira K, Toyama K, Kanzaki K, Fukunaga K, Sudo Y, Ichinose H, Ikeda M, Iwata N, Ozaki N, Suzuki H, Higuchi M, Suhara T, Yuasa S, Miyakawa T.
Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders. Molecular Brain 1: 6 (2008).

Kobayashi K*, Ikeda Y, Haneda H, Suzuki H.
Chronic fluoxetine bidirectionally modulates potentiating effects of serotonin on the hippocampal mossy fiber synaptic transmission. Journal of Neuroscience 28: 6272-6280 (2008). * Corresponding author

2007

Kobayashi K*, Suzuki H.
Dopamine selectively potentiates hippocampal mossy fiber to CA3 synaptic transmission. Neuropharmacology 52: 552-561 (2007). * Corresponding author

2006

Kobayashi K*, Ikeda Y, Suzuki H.
Locomotor activity correlates with modifications of hippocampal mossy fibre synaptic transmission. European Journal of Neuroscience 24: 1867-1873 (2006). * Corresponding author

2004

Kobayashi K, Poo M.-m.
Spike train timing-dependent associative modification of hippocampal CA3 recurrent synapses by mossy fibers. Neuron 41: 445-454 (2004).

2003

Mori-Kawakami F, Kobayashi K, Takahashi T.
Developmental decrease in synaptic facilitation at the mouse hippocampal mossy fibre synapse. Journal of Physiology 553: 37-48 (2003).

1999

Sakaguchi G, Manabe T, Kobayashi K, Orita S, Sasaki T, Naito A, Maeda M, Igarashi H, Katsuura G, Nishioka H, Mizoguchi A, Itohara S, Takahashi T, Takai Y.
Doc2α is an activity-dependent modulator of excitatory synaptic transmission. European Journal of Neuroscience 11: 4262-4268 (1999).

Kobayashi K*, Manabe T, Takahashi T.
Calcium-dependent mechanisms involved in presynaptic long-term depression at the hippocampal mossy fibre-CA3 synapse. European Journal of Neuroscience 11: 1633-1638 (1999). * Corresponding author

Kobayashi K, Ishii S, Kume K, Takahashi T, Shimizu T, Manabe T.
Platelet-activating factor receptor is not required for long-term potentiation in the hippocampal CA1 region. European Journal of Neuroscience 11: 1313-1316 (1999).

1997

Ikeda K, Kobayashi K, Kobayashi T, Ichikawa T, Kumanishi T, Kishida H, Yano R, Manabe T.
Functional coupling of the nociceptin/orphanin FQ receptor with the G-protein-activated K⁺ (GIRK) channel. Molecular Brain Research 45: 117-126 (1997).

1996

Kobayashi K, Manabe T, Takahashi T.
Presynaptic long-term depression at the hippocampal mossy fiber-CA3 synapse. Science 273: 648-650 (1996).

Yokoi M, Kobayashi K, Manabe T, Takahashi T, Sakaguchi I, Katsuura G, Shigemoto R, Ohishi H, Nomura S, Nakamura K, Nakao K, Katsuki M, Nakanishi S.
Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2. Science 273: 645-647 (1996).

1995

Kobayashi K, Tachibana M.
Ca²⁺ regulation in the presynaptic terminals of goldfish retinal bipolar cells. Journal of Physiology 483: 79-94 (1995).

Kobayashi K, Sakaba T, Tachibana M.
Potentiation of Ca²⁺ transient in the presynaptic terminals of goldfish retinal bipolar cells. Journal of Physiology 482: 7-13 (1995).

Takei Y, Harada A, Takeda S, Kobayashi K, Terada S, Noda T, Takahashi T, Hirokawa N.
Synapsin I deficiency results in the structural change in the presynaptic terminals in the murine nervous system. Journal of Cell Biology 131: 1789-1800 (1995).

1993

Tachibana M, Okada T, Arimura T, Kobayashi K, Piccolino M.
Dihydropyridine-sensitive calcium current mediates neurotransmitter release from bipolar cells of the goldfish retina. Journal of Neuroscience 13: 2898-2909 (1993).

Tachibana M, Okada T, Arimura T, Kobayashi K.
Dihydropyridine-sensitive calcium current mediates neurotransmitter release from retinal bipolar cells. Annals of the New York Academy of Sciences 707: 359-361 (1993).

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